ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΡ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠΉ ΠΌΠ΅ΠΆΠ΄Ρ Π³ΡΠ°Π½ΠΈΡΠ°ΠΌΠΈ ΡΠ΅Π³ΡΠ»ΡΡΠΎΡΠ½ΡΡ Π΄ΠΎΠΌΠ΅Π½ΠΎΠ² Π³Π΅Π½Π° Abd-B Ρ Drosophila melanogaster
ΠΠ»Ρ ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π³Π΅Π½ΠΎΠΌΠ° ΠΎΡΠ΅Π½Ρ Π±ΠΎΠ»ΡΡΠΎΠ΅ Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅ ΠΈΠΌΠ΅Π΅Ρ ΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΡ Π½Π΅Π·Π°Π²ΠΈΡΠΈΠΌΡΡ Π΄ΠΎΠΌΠ΅Π½ΠΎΠ² ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ Π³Π΅Π½ΠΎΠ². ΠΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΡ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΠ°ΠΊΠΈΡ Π΄ΠΎΠΌΠ΅Π½ΠΎΠ² Π² Π½Π°ΡΡΠΎΡΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡ ΠΌΠ°Π»ΠΎ ΠΈΠ·ΡΡΠ΅Π½Ρ. Π‘ΡΡΠ΅ΡΡΠ²ΡΠ΅Ρ Π³ΠΈΠΏΠΎΡΠ΅Π·Π°, ΠΏΠΎΡΡΡΠ»ΠΈΡΡΡΡΠ°Ρ, ΡΡΠΎ ΡΡΠ½ΠΊΡΠΈΡ Π³ΡΠ°Π½ΠΈΡ Π΄ΠΎΠΌΠ΅Π½ΠΎΠ² Ρ ΡΠ°Π·Π½ΡΠΌΠΈ ΠΏΠ°ΡΡΠ΅ΡΠ½Π°ΠΌΠΈ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ Π²ΡΠΏΠΎΠ»Π½ΡΡΡ ΠΈΠ½ΡΡΠ»ΡΡΠΎΡΡ. ΠΠ½ΡΡΠ»ΡΡΠΎΡΡ — ΡΡΠΎ Π³^ΠΎΡΠ΅Π³ΡΠ»ΡΡΠΎΡΠ½ΡΠ΅ ΡΠ»Π΅ΠΌΠ΅Π½ΡΡ, ΠΊΠΎΡΠΎΡΡΠ΅ ΡΠΏΠΎΡΠΎΠ±Π½Ρ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎ ΠΈΠ·ΠΎΠ»ΠΈΡΠΎΠ²Π°ΡΡ ΠΏΡΠΎΠΌΠΎΡΠΎΡ… Π§ΠΈΡΠ°ΡΡ Π΅ΡΡ >
- Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- ΠΡΠ΄Π΅ΡΠΆΠΊΠ°
- ΠΠΈΡΠ΅ΡΠ°ΡΡΡΠ°
- ΠΡΡΠ³ΠΈΠ΅ ΡΠ°Π±ΠΎΡΡ
- ΠΠΎΠΌΠΎΡΡ Π² Π½Π°ΠΏΠΈΡΠ°Π½ΠΈΠΈ
Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅
- Π‘ΠΠΠ‘ΠΠ ΠΠ‘ΠΠΠΠ¬ΠΠ£ΠΠΠ«Π₯ Π‘ΠΠΠ ΠΠ©ΠΠΠΠ
- 1. ΠΠΠΠΠ ΠΠΠ’ΠΠ ΠΠ’Π£Π Π«
- 1. 1. Π Π°Π·Π²ΠΈΡΠΈΠ΅ Drosophila melanogaster. Π ΠΎΠ»Ρ Π³ΠΎΠΌΠ΅ΠΎΠ·ΠΈΡΠ½ΡΡ
Π³Π΅Π½ΠΎΠ² Π² ΠΏΡΠΎΡΠ΅ΡΡΠ΅ ΡΠΌΠ±ΡΠΈΠΎΠ³Π΅Π½Π΅Π·Π°
- 1. 1. 1. Π‘Π΅Π³ΠΌΠ΅Π½ΡΠ°ΡΠΈΡ Π² ΠΏΡΠΎΡΠ΅ΡΡΠ΅ ΡΠ°Π·Π²ΠΈΡΠΈΡ Drosophila melanogaster: Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ
- 1. 1. 2. Π ΠΎΠ»Ρ Π³ΠΎΠΌΠ΅ΠΎΠ·ΠΈΡΠ½ΡΡ Π³Π΅Π½ΠΎΠ² Π² ΠΏΡΠΎΡΠ΅ΡΡΠ΅ ΡΠΌΠ±ΡΠΈΠΎΠ³Π΅Π½Π΅Π·Π°
- 1. 2. Π Π΅Π³ΡΠ»ΡΡΠΈΡ Bithorax ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ°
- 1. 2. 1. ΠΠ±ΡΠΈΠ΅ ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΡ
- 1. 2. 2. Π€Π°Π·Ρ ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΠ₯-Π‘
- 1. 2. 3. ΠΠ΅Π»ΠΊΠΈ Π³ΡΡΠΏΠΏ Polycomb ΠΈ Trithorax ΠΈ ΠΈΡ ΡΠΎΠ»Ρ Π² ΡΠ΅Π³ΡΠ»ΡΡΠΈΠΈ ΠΠ₯-Π‘
- 1. 3. ΠΡΠ°Π½ΠΈΡΡ ΡΠ΅Π³ΡΠ»ΡΡΠΎΡΠ½ΡΡ
Π΄ΠΎΠΌΠ΅Π½ΠΎΠ² Π³Π΅Π½Π° Abd-B. ΠΠ½ΡΡΠ»ΡΡΠΎΡΡ.21 '
- 1. 3. 1. ΠΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΡ ΡΠ΅Π³ΡΠ»ΡΡΠΎΡΠ½ΠΎΠΉ ΠΎΠ±Π»Π°ΡΡΠΈ Π³Π΅Π½Π° Abd-B
- 1. 3. 2. ΠΡΠ°Π½ΠΈΡΠ°Fab-7.23,
- 1. 3. 3. ΠΡΠ°Π½ΠΈΡΠ° Fab
- 1. 3. 4. ΠΡΠ°Π½ΠΈΡΠ° ΠΠ΅Ρ
- 1. 3. 5. ΠΡΠ°Π½ΠΈΡΠ° Fab
- 1. 4. ΠΠΎΠ΄Π΅Π»ΠΈ ΡΠ΅Π³ΡΠ»ΡΡΠΈΠΈ Π³Π΅Π½Π° Abd-B
- 1. 4. 1. ΠΠ·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ ΠΌΠ΅ΠΆΠ΄Ρ ΠΈΠ½ΡΡΠ»ΡΡΠΎΡΠ°ΠΌΠΈ
- 1. 4. 2. ΠΠ½ΡΠΈ-ΠΈΠ½ΡΡΠ»ΡΡΠΎΡΠ½ΡΠ΅ ΡΠ»Π΅ΠΌΠ΅Π½ΡΡ. Promoter Targeting Sequence
- 1. 5. ΠΠ΅Π»ΠΊΠΎΠ²ΡΠ΅ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅! itm Π³ΡΠ°Π½ΠΈΡ ΡΠ΅Π³ΡΠ»ΡΡΠΎΡΠ½ΡΡ
Π΄ΠΎΠΌΠ΅Π½ΠΎΠ² Bithorax ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ°
- 1. 5. 1. ΠΠ΅Π»ΠΎΠΊ dCTCF
- 1. 5. 2. ΠΠ΅Π»ΠΎΠΊ Π‘Π
- 1. 5. 3. ΠΡΡΠ³ΠΈΠ΅ Π±Π΅Π»ΠΊΠΎΠ²ΡΠ΅ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΡ Π³ΡΠ°Π½ΠΈΡ Bithorax ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ°
- 1. 1. Π Π°Π·Π²ΠΈΡΠΈΠ΅ Drosophila melanogaster. Π ΠΎΠ»Ρ Π³ΠΎΠΌΠ΅ΠΎΠ·ΠΈΡΠ½ΡΡ
Π³Π΅Π½ΠΎΠ² Π² ΠΏΡΠΎΡΠ΅ΡΡΠ΅ ΡΠΌΠ±ΡΠΈΠΎΠ³Π΅Π½Π΅Π·Π°
- 2. 1. ΠΠ΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΌΠ΅ΡΠΎΠ΄Ρ
- 2. 1. 1. ΠΠΈΠ½ΠΈΠΈ ΠΈ ΠΌΡΡΠ°ΡΠΈΠΈ Drosophila melanogaster
- 2. 1. 2. Π’ΡΠ°Π½ΡΡΠΎΡΠΌΠ°ΡΠΈΡ ΡΠΌΠ±ΡΠΈΠΎΠ½ΠΎΠ² Drosophila melanogaster ΠΈ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΡΡΠ°Π½ΡΠ³Π΅Π½Π½ΡΡ Π»ΠΈΠ½ΠΈΠΉ
- 2. 1. 3. Π€Π΅Π½ΠΎΡΠΈΠΏΠΈΡΠ΅ΡΠΊΠΈΠΉ Π°Π½Π°Π»ΠΈΠ· ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ Π³Π΅Π½Π° mini-white Π² ΡΡΠ°Π½ΡΠ³Π΅Π½Π½ΡΡ Π»ΠΈΠ½ΠΈΡΡ
- 2. 1. 4. ΠΠ΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠΊΡΠ΅ΡΠΈΠ²Π°Π½ΠΈΡ
- 2. 2. ΠΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΠ΅ ΠΌΠ΅ΡΠΎΠ΄Ρ
- 2. 2. 1. ΠΡΠΈΠ³ΠΎΡΠΎΠ²Π»Π΅Π½ΠΈΠ΅ ΠΊΠΎΠΌΠΏΠ΅ΡΠ΅Π½ΡΠ½ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ Π»ΠΈΠ½ΠΈΠΈ E. coli DH5a
- 2. 2. 2. Π’ΡΠ°Π½ΡΡΠΎΡΠΌΠ°ΡΠΈΡ Π±Π°ΠΊΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΏΠ»Π°Π·ΠΌΠΈΠ΄Π½ΠΎΠΉ ΠΠΠ
- 2. 2. 3. ΠΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΏΠ»Π°Π·ΠΌΠΈΠ΄Π½ΠΎΠΉ ΠΠΠ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΡΠ΅Π»ΠΎΡΠ½ΠΎΠ³ΠΎ Π»ΠΈΠ·ΠΈΡΠ°
- 2. 2. 4. ΠΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ Π³Π΅Π½ΠΎΠΌΠ½ΠΎΠΉ ΠΠΠ ΠΈΠ· Π΄ΡΠΎΠ·ΠΎΡΠΈΠ»Ρ
- 2. 2. 5. ΠΠ΅ΡΠ΅ΠΎΡΠ°ΠΆΠ΄Π΅Π½ΠΈΠ΅ ΠΠΠ
- 2. 2. 6. ΠΠΎΡΠΈΠ·ΠΎΠ½ΡΠ°Π»ΡΠ½ΡΠΉ Π³Π΅Π»Ρ ΡΠ»Π΅ΠΊΡΡΠΎΡΠΎΡΠ΅Π·
- 2. 2. 7. ΠΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠΎΠ² ΠΠΠ ΠΈΠ· Π³Π΅Π»Ρ ΠΈ ΠΎΡΠΈΡΡΠΊΠ° ΠΠΠ ΠΎΡ ΠΏΡΠΎΠ΄ΡΠΊΡΠΎΠ² ΡΠ΅ΡΠΌΠ΅Π½ΡΠ°ΡΠΈΠ²Π½ΡΡ ΡΠ΅Π°ΠΊΡΠΈΠΉ
- 2. 2. 8. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ Π½ΡΠΊΠ»Π΅ΠΈΠ½ΠΎΠ²ΡΡ ΠΊΠΈΡΠ»ΠΎΡ
- 2. 2. 9. ΠΠ΅ΡΠΎΠ΄ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠ°Π·Π½ΠΎΠΉ ΡΠ΅ΠΏΠ½ΠΎΠΉ ΡΠ΅Π°ΠΊΡΠΈΠΈ (ΠΠ¦Π )
- 2. 2. 12. Π Π΅ΡΡΡΠΈΠΊΡΠΈΡ ΠΏΠ»Π°Π·ΠΌΠΈΠ΄Π½ΠΎΠΉ ΠΠΠ
- 2. 2. 13. ΠΠ΅ΡΠΎΠ΄ Π°Π½Π°Π»ΠΈΠ·Π° ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΠ»Π΅ΠΊΡΡΠΎΡΠΎΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΠΎΠ΄Π²ΠΈΠΆΠ½ΠΎΡΡΠΈ Π² ΠΏΠΎΠ»ΠΈΠ°ΠΊΡΠΈΠ»Π°ΠΌΠΈΠ΄Π½ΠΎΠΌ Π³Π΅Π»Π΅
- 2. 3. 14. Π‘Π°ΡΠ·Π΅ΡΠ½-Π±Π»ΠΎΡ-Π°Π½Π°Π»ΠΈΠ·
- 2. 3. ΠΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΠΌΡΠ΅ Π² ΡΠ°Π±ΠΎΡΠ΅ ΠΎΠ»ΠΈΠ³ΠΎΠ½ΡΠΊΠ»Π΅ΠΎΡΠΈΠ΄Ρ
- 2. 4. ΠΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΡΡΠ°Π½ΡΠ³Π΅Π½Π½ΡΡ
ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΠΉ
- 2. 4. 1. ΠΡΠ½ΠΎΠ²Π½ΡΠ΅ Π²Π΅ΠΊΡΠΎΡΡ, ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΠΌΡΠ΅ Π² ΡΠ°Π±ΠΎΡΠ΅
- 2. 4. 2. Π‘ΠΎΠ·Π΄Π°Π½ΠΈΠ΅ ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΠΉ
- 3. 1. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΠΈ Π Π°Π²-8 ΠΈΠ½ΡΡΠ»ΡΡΠΎΡΠ° Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΎΠ²Π°ΡΡ Π½Π° Π±ΠΎΠ»ΡΡΠΈΡ Π΄ΠΈΡΡΠ°Π½ΡΠΈΡΡ
- 3. 2. ΠΠ°Π»ΠΈΡΠΈΠ΅ ΡΠ°ΠΉΡΠΎΠ² Π±Π΅Π»ΠΊΠ° ΡΠ‘Π’Π‘Π Π½Π΅ΠΎΠ±Ρ ΠΎΠ΄ΠΈΠΌΠΎ Π΄Π»Ρ ΠΎΡΡΡΠ΅ΡΡΠ²Π»Π΅Π½ΠΈΡ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΌΠ΅ΠΆΠ΄Ρ Π΄Π²ΡΠΌΡ ΠΊΠΎΠΏΠΈΡΠΌΠΈ Π Π°Π²-8 ΠΈΠ½ΡΡΠ»ΡΡΠΎΡΠ°
- 3. 3. ΠΡΠ°Π½ΠΈΡΡ Π Π°Π²-7 ΠΈ Π Π°Π²-8 ΡΠΏΠΎΡΠΎΠ±Π½Ρ ΠΊ ΠΎΡΡΡΠ΅ΡΡΠ²Π»Π΅Π½ΠΈΡ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ Π΄ΡΡΠ³ Ρ Π΄ΡΡΠ³ΠΎΠΌ
- 3. 4. ΠΡΠ°Π½ΠΈΡΡ Π Π°Π²-7 ΠΈ Π Π’8/Π Π°Π²-8 ΡΠΏΠΎΡΠΎΠ±Π½Ρ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΎΠ²Π°ΡΡ Ρ ΠΏΡΠ΅Π΄ΠΏΡΠΎΠΌΠΎΡΠΎΡΠ½ΠΎΠΉ ΠΎΠ±Π»Π°ΡΡΡΡ Π³Π΅Π½Π° Π°Π²Π±-Π²
ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΡ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠΉ ΠΌΠ΅ΠΆΠ΄Ρ Π³ΡΠ°Π½ΠΈΡΠ°ΠΌΠΈ ΡΠ΅Π³ΡΠ»ΡΡΠΎΡΠ½ΡΡ Π΄ΠΎΠΌΠ΅Π½ΠΎΠ² Π³Π΅Π½Π° Abd-B Ρ Drosophila melanogaster (ΡΠ΅ΡΠ΅ΡΠ°Ρ, ΠΊΡΡΡΠΎΠ²Π°Ρ, Π΄ΠΈΠΏΠ»ΠΎΠΌ, ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½Π°Ρ)
Π Π΅Π³ΡΠ»ΡΡΠΈΡ ΡΡΠ°Π½ΡΠΊΡΠΈΠΏΡΠΈΠΈ Π³Π΅Π½ΠΎΠ² ΡΡΠΊΠ°ΡΠΈΠΎΡ Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΠ΅ΡΡΡ ΡΡΠ΄ΠΎΠΌ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠ΅ΠΉ, ΡΠ²ΡΠ·Π°Π½Π½ΡΡ Ρ ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ΠΌ ΠΊΠΎΠΎΡΠ΄ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ Π³Π΅Π½ΠΎΠ² Π² ΡΠ»ΠΎΠΆΠ½ΠΎΠΎΡΠ³Π°Π½ΠΈΠ·ΠΎΠ²Π°Π½Π½ΠΎΠΉ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΠ΅. ΠΠ°ΠΆΠ΄ΡΠΉ ΡΠΈΠΏ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΌΠ½ΠΎΠ³ΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ° Ρ Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΠ΅ΡΡΡ ΡΠΎΠ±ΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΡΠ½ΠΈΠΊΠ°Π»ΡΠ½ΠΎΠΉ ΠΊΠΎΠΌΠ±ΠΈΠ½Π°ΡΠΈΠ΅ΠΉ Π±Π΅Π»ΠΊΠΎΠ²ΡΡ ΡΠ°ΠΊΡΠΎΡΠΎΠ², ΠΏΠΎΡΠ²Π»Π΅Π½ΠΈΠ΅ ΠΊΠΎΡΠΎΡΡΡ Π² Ρ ΠΎΠ΄Π΅ Π΄Π½ΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²ΠΊΠΈ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠΈΠ²Π°Π΅ΡΡΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠΉ ΡΠ΅Π³ΡΠ»ΡΡΠΈΠ΅ΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΊΠΎΠ΄ΠΈΡΡΡΡΠΈΡ ΠΈΡ Π³Π΅Π½ΠΎΠ². Π’Π°ΠΊΠ°Ρ Π²ΡΡΠΎΠΊΠΎΡΡΡΠ΅ΠΊΡΠΈΠ²Π½Π°Ρ ΠΏΡΠΎΡΡΡΠ°Π½ΡΡΠ²Π΅Π½Π½ΠΎ-Π²ΡΠ΅ΠΌΠ΅Π½Π½Π°Ρ ΡΠ΅Π³ΡΠ»ΡΡΠΈΡ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ Π³Π΅Π½ΠΎΠ² ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠΈΠ²Π°Π΅ΡΡΡ Π·Π° ΡΡΠ΅Ρ ΡΠ»ΠΎΠΆΠ½ΠΎΡΡΡΡΠΎΠ΅Π½Π½ΡΡ ΠΈ, ΠΊΠ°ΠΊ ΠΏΡΠ°Π²ΠΈΠ»ΠΎ, ΠΏΡΠΎΡΡΠΆΠ΅Π½Π½ΡΡ ΡΠ΅Π³ΡΠ»ΡΡΠΎΡΠ½ΡΡ ΠΎΠ±Π»Π°ΡΡΠ΅ΠΉ, ΠΊΠΎΡΠΎΡΡΠ΅ ΡΠΎΡΡΠΎΡΡ ΠΈΠ· ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠ»Π΅ΠΌΠ΅Π½ΡΠΎΠ², Π°ΠΊΡΠΈΠ²ΠΈΡΡΡΡΠΈΡ ΡΡΠ°Π½ΡΠΊΡΠΈΠΏΡΠΈΡ (ΡΠ½Ρ Π°Π½ΡΠ΅ΡΠΎΠ²) ΠΈΠ»ΠΈ ΡΠ΅ΠΏΡΠ΅ΡΡΠΈΡΡΡΡΠΈΡ Π΅Π΅ (ΡΠ°ΠΉΠ»Π΅Π½ΡΠ΅ΡΠΎΠ²).
ΠΠ»Ρ ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π³Π΅Π½ΠΎΠΌΠ° ΠΎΡΠ΅Π½Ρ Π±ΠΎΠ»ΡΡΠΎΠ΅ Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅ ΠΈΠΌΠ΅Π΅Ρ ΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΡ Π½Π΅Π·Π°Π²ΠΈΡΠΈΠΌΡΡ Π΄ΠΎΠΌΠ΅Π½ΠΎΠ² ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ Π³Π΅Π½ΠΎΠ². ΠΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΡ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΠ°ΠΊΠΈΡ Π΄ΠΎΠΌΠ΅Π½ΠΎΠ² Π² Π½Π°ΡΡΠΎΡΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡ ΠΌΠ°Π»ΠΎ ΠΈΠ·ΡΡΠ΅Π½Ρ. Π‘ΡΡΠ΅ΡΡΠ²ΡΠ΅Ρ Π³ΠΈΠΏΠΎΡΠ΅Π·Π°, ΠΏΠΎΡΡΡΠ»ΠΈΡΡΡΡΠ°Ρ, ΡΡΠΎ ΡΡΠ½ΠΊΡΠΈΡ Π³ΡΠ°Π½ΠΈΡ Π΄ΠΎΠΌΠ΅Π½ΠΎΠ² Ρ ΡΠ°Π·Π½ΡΠΌΠΈ ΠΏΠ°ΡΡΠ΅ΡΠ½Π°ΠΌΠΈ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ Π²ΡΠΏΠΎΠ»Π½ΡΡΡ ΠΈΠ½ΡΡΠ»ΡΡΠΎΡΡ. ΠΠ½ΡΡΠ»ΡΡΠΎΡΡ — ΡΡΠΎ Π³^ΠΎΡΠ΅Π³ΡΠ»ΡΡΠΎΡΠ½ΡΠ΅ ΡΠ»Π΅ΠΌΠ΅Π½ΡΡ, ΠΊΠΎΡΠΎΡΡΠ΅ ΡΠΏΠΎΡΠΎΠ±Π½Ρ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎ ΠΈΠ·ΠΎΠ»ΠΈΡΠΎΠ²Π°ΡΡ ΠΏΡΠΎΠΌΠΎΡΠΎΡ ΠΎΡ ΡΠ½Ρ Π°Π½ΡΠ΅ΡΠ°, Π΅ΡΠ»ΠΈ ΡΠ°ΡΠΏΠΎΠ»Π°Π³Π°ΡΡΡΡ ΠΌΠ΅ΠΆΠ΄Ρ Π½ΠΈΠΌΠΈ, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΎΠ³ΡΠ°Π½ΠΈΡΠΈΠ²Π°ΡΡ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½ΠΈΠ΅ ΡΠ΅ΠΏΡΠ΅ΡΡΠΈΠΈ (Cai et al., 1995; Gerasimova et al., 1996).
ΠΠ»Ρ Π·Π°ΠΏΡΡΠΊΠ° ΡΠ°Π±ΠΎΡΡ Π³Π΅Π½Π° Π²Π°ΠΆΠ½ΠΎ, ΡΡΠΎΠ±Ρ ΡΠ½Ρ Π°Π½ΡΠ΅Ρ ΠΏΡΠ°Π²ΠΈΠ»ΡΠ½ΠΎ Π½Π°Ρ ΠΎΠ΄ΠΈΠ» ΠΏΡΠΎΠΌΠΎΡΠΎΡ, Π½Π΅ΡΠΌΠΎΡΡΡ Π½Π° ΡΠΎ, ΡΡΠΎ ΡΠ°ΡΡΡΠΎΡΠ½ΠΈΠ΅ ΠΌΠ΅ΠΆΠ΄Ρ Π½ΠΈΠΌΠΈ ΠΈΠ½ΠΎΠ³Π΄Π° ΠΌΠΎΠΆΠ΅Ρ Π΄ΠΎΡΡΠΈΠ³Π°ΡΡ Π½Π΅ΡΠΊΠΎΠ»ΡΠΊΠΈΡ ΡΠΎΡ ΡΠΏΠ½. Π‘ΡΡΠ΅ΡΡΠ²ΡΡΡ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΠ΅ Π΄ΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΡΡΠ²Π° ΡΠΎΠ³ΠΎ, ΡΡΠΎ Π² ΠΏΡΠΎΡΠ΅ΡΡΠ΅ Π°ΠΊΡΠΈΠ²Π°ΡΠΈΠΈ ΡΠ½Ρ Π°Π½ΡΠ΅Ρ ΠΈ ΠΏΡΠΎΠΌΠΎΡΠΎΡ ΡΠ±Π»ΠΈΠΆΠ°ΡΡΡΡ Π² ΠΏΡΠΎΡΡΡΠ°Π½ΡΡΠ²Π΅, Π° Π½Π°Ρ ΠΎΠ΄ΡΡΠΈΠΉΡΡ ΠΌΠ΅ΠΆΠ΄Ρ Π½ΠΈΠΌΠΈ ΡΡΠ°ΡΡΠΎΠΊ ΠΠΠ Π²ΡΠΏΠ΅ΡΠ»ΠΈΠ²Π°Π΅ΡΡΡ (West et al., 2005; de Laat et al., 2008, Maeda et. al 2007). ΠΠ΄Π½Π°ΠΊΠΎ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΡ, ΠΊΠΎΠ½ΡΡΠΎΠ»ΠΈΡΡΡΡΠΈΠ΅ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΡΡ ΠΊΠΎΠΌΠΌΡΠ½ΠΈΠΊΠ°ΡΠΈΡ ΠΌΠ΅ΠΆΠ΄Ρ ΡΠ½Ρ Π°Π½ΡΠ΅ΡΠ°ΠΌΠΈ ΠΈ ΠΏΡΠΎΠΌΠΎΡΠΎΡΠ°ΠΌΠΈ Π½Π° Π±ΠΎΠ»ΡΡΠΈΡ Π΄ΠΈΡΡΠ°Π½ΡΠΈΡΡ , Π΄ΠΎ ΡΠΈΡ ΠΏΠΎΡ ΠΌΠ°Π»ΠΎ ΠΈΠ·ΡΡΠ΅Π½Ρ.
Π£Π΄ΠΎΠ±Π½ΠΎΠΉ ΠΌΠΎΠ΄Π΅Π»ΡΡ Π΄Π»Ρ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΠΎΠ² Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΌΠ΅ΠΆΠ΄Ρ ΡΠ½Ρ Π°Π½ΡΠ΅ΡΠ°ΠΌΠΈ ΠΈ ΠΏΡΠΎΠΌΠΎΡΠΎΡΠ°ΠΌΠΈ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠ΅Π³ΡΠ»ΡΡΠΎΡΠ½Π°Ρ ΠΎΠ±Π»Π°ΡΡΡ Abd-B Π³Π΅Π½Π°, Π²Ρ ΠΎΠ΄ΡΡΠ΅Π³ΠΎ Π² ΡΠΎΡΡΠ°Π² Bithorax ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° Drosophila melanogaster. Π Π΅Π³ΡΠ»ΡΡΠΎΡΠ½Π°Ρ ΠΎΠ±Π»Π°ΡΡΡ Abd-B ΡΠ°Π·ΠΌΠ΅ΡΠΎΠΌ ΠΎΠΊΠΎΠ»ΠΎ 60 ΡΠΏΠ½ ΡΠΎΠ΄Π΅ΡΠΆΠΈΡ 4 ΡΠ½Ρ Π°Π½ΡΠ΅ΡΠ° {iab-5, iab-6, iab-7, iab-8), ΠΊΠ°ΠΆΠ΄ΡΠΉ ΠΈΠ· ΠΊΠΎΡΠΎΡΡΡ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ΅Ρ ΡΡΠΎΠ²Π΅Π½Ρ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ Π³Π΅Π½Π° Π² ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΡΡΡΠ΅ΠΌ Π±ΡΡΡΠ½ΠΎΠΌ ΠΏΠ°ΡΠ°ΡΠ΅Π³ΠΌΠ΅Π½ΡΠ΅ (ΠΠ‘10−13). ΠΠ½Ρ Π°Π½ΡΠ΅ΡΡ ΠΎΡΠ΄Π΅Π»Π΅Π½Ρ Π΄ΡΡΠ³ ΠΎΡ Π΄ΡΡΠ³Π° Π³ΡΠ°Π½ΠΈΡΠ°ΠΌΠΈ, ΡΡΠΈ ΠΈΠ· ΠΊΠΎΡΠΎΡΡΡ Π±ΡΠ»ΠΈ ΠΏΠΎΠ΄ΡΠΎΠ±Π½ΠΎ ΠΈΠ·ΡΡΠ΅Π½Ρ: ΠΠ΅Ρ. Fab-7 ΠΈ Fab-8. ΠΡΠΈ Π³ΡΠ°Π½ΠΈΡΡ ΡΡΡΡΠΎΠ΅Π½Ρ ΡΡ ΠΎΠ΄Π½ΡΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠΌ ΠΈ ΡΠΎΠ΄Π΅ΡΠΆΠ°Ρ Π² ΡΠ²ΠΎΠ΅ΠΌ ΡΠΎΡΡΠ°Π²Π΅ ΠΈΠ½ΡΡΠ»ΡΡΠΎΡ ΠΈ ΠΏΡΠΈΠ»Π΅Π³Π°ΡΡΠΈΠΉ ΠΊ Π½Π΅ΠΌΡ ΡΠ°ΠΉΠ»Π΅Π½ΡΠ΅Ρ (Karch et al., 1994; Barges et al., 2000; Zhou et al., 1999; Gruzdeva et al., y. 2005). Π’Π°ΠΊΠΈΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠΌ, ΠΈΠΌΠ΅Π΅Ρ ΠΌΠ΅ΡΡΠΎ ΠΏΠ°ΡΠ°Π΄ΠΎΠΊΡΠ°Π»ΡΠ½Π°Ρ ΡΠΈΡΡΠ°ΡΠΈΡ, ΠΏΡΠΈ ΠΊΠΎΡΠΎΡΠΎΠΉ ΠΎΠΊΡΡΠΆΠ΅Π½Π½ΡΠ΅ ΠΈΠ½ΡΡΠ»ΡΡΠΎΡΠ°ΠΌΠΈ ΡΠ½Ρ Π°Π½ΡΠ΅ΡΡ ΡΠΏΠΎΡΠΎΠ±Π½Ρ Π°ΠΊΡΠΈΠ²ΠΈΡΠΎΠ²Π°ΡΡ ΡΠ²ΠΎΠΉ ΠΏΡΠΎΠΌΠΎΡΠΎΡ^ ΠΡΡ ΠΎΠ΄Ρ ΠΈΠ· ΡΡΠΎΠ³ΠΎ, ΠΌΠΎΠΆΠ½ΠΎ ΠΏΡΠ΅Π΄ΠΏΠΎΠ»ΠΎΠΆΠΈΡΡ, ΡΡΠΎ ΠΈΠ½ΡΡΠ»ΡΡΠΎΡΡ Bithorax ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° ΠΎΠ±Π»Π°Π΄Π°ΡΡ Π΄ΠΎΠΏΠΎΠ»Π½ΠΈΡΠ΅Π»ΡΠ½ΡΠΌΠΈ ΡΡΠ½ΠΊΡΠΈΡΠΌΠΈ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π³ΡΠ°Π½ΠΈΡ ΠΠ΅Ρ ΠΈ Fab-7 ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΎ, ΡΡΠΎ ΠΈΠ½ΡΡΠ»ΡΡΠΎΡΡ Π³ΡΠ°Π½ΠΈΡ ΡΠΏΠΎΡΠΎΠ±Π½Ρ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΎΠ²Π°ΡΡ ΡΠΎ ΡΠ²ΠΎΠΈΠΌΠΈ ΠΊΠΎΠΏΠΈΡΠΌΠΈ Π½Π° Π±ΠΎΠ»ΡΡΠΈΡ Π΄ΠΈΡΡΠ°Π½ΡΠΈΡΡ (Muller et al., 1999, Bantingnies et al., 2003, Gruzdeva et al., 2005. Vazquez et al., 2006, Kyrchanova et al., 2007). ΠΠ»Ρ Π³ΡΠ°Π½ΠΈΡΡ Fab-7 Π±ΡΠ»ΠΎ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΠΎΠ½Π° ΡΠ±Π»ΠΈΠΆΠ°Π΅ΡΡΡ Ρ ΠΏΡΠ΅Π΄ΠΏΡΠΎΠΌΠΎΡΠΎΡΠ½ΠΎΠΉ ΠΎΠ±Π»Π°ΡΡΡΡ Π³Π΅Π½Π° Abd-B Π² Π½Π΅ΠΊΠΎΡΠΎΡΡΡ ΡΠΊΠ°Π½ΡΡ (Cleard et al., 2006). Π’Π°ΠΊΠΈΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠΌ, ΠΌΠΎΠΆΠ½ΠΎ ΠΏΡΠ΅Π΄ΠΏΠΎΠ»ΠΎΠΆΠΈΡΡ, ΡΡΠΎ Π³ΡΠ°Π½ΠΈΡΡ ΡΠ΅Π³ΡΠ»ΡΡΠΎΡΠ½ΡΡ Π΄ΠΎΠΌΠ΅Π½ΠΎΠ² ΠΎΡΠ²Π΅ΡΠ°ΡΡ Π·Π° ΠΏΡΠΎΡΡΡΠ°Π½ΡΡΠ²Π΅Π½Π½ΡΡ ΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΡ Π»ΠΎΠΊΡΡΠ° ΠΠ₯-Π‘ ΠΈ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΡΡ ΠΊΠΎΠΌΠΌΡΠ½ΠΈΠΊΠ°ΡΠΈΡ ΠΌΠ΅ΠΆΠ΄Ρ ΡΠ½Ρ Π°Π½ΡΠ΅ΡΠ°ΠΌΠΈ ΠΈ ΠΏΡΠΎΠΌΠΎΡΠΎΡΠ°ΠΌΠΈ Π΅Π³ΠΎ Π³Π΅Π½ΠΎΠ².
Π Π½Π°ΡΡΠΎΡΡΠ΅ΠΌΡ ΠΌΠΎΠΌΠ΅Π½ΡΡ Π½Π°ΠΊΠΎΠΏΠ»Π΅Π½Ρ Π½Π΅ΠΊΠΎΡΠΎΡΡΠ΅ Π΄Π°Π½Π½ΡΠ΅ ΠΎ Π±Π΅Π»ΠΊΠΎΠ²ΡΡ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠ°Ρ Π³ΡΠ°Π½ΠΈΡ ΡΠ΅Π³ΡΠ»ΡΡΠΎΡΠ½ΡΡ Π΄ΠΎΠΌΠ΅Π½ΠΎΠ² (Moon et al. 2005; Holohan et al., 2007; Hagstrom et al., 1996; Mohan et al., 2007; Aoki et al., 2008). Π ΡΠ°ΡΡΠ½ΠΎΡΡΠΈ, ΠΏΡΠΎΠ΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΠΎΠ²Π°Π½ΠΎ, ΡΡΠΎ Ρ Π³ΡΠ°Π½ΠΈΡΠ°ΠΌΠΈ ΡΠ²ΡΠ·ΡΠ²Π°ΡΡΡΡ ΠΈΠ·Π²Π΅ΡΡΠ½ΡΠ΅ ΠΈΠ½ΡΡΠ»ΡΡΠΎΡΠ½ΡΠ΅ Π±Π΅Π»ΠΊΠΈ Π΄ΡΠΎΠ·ΠΎΡΠΈΠ»Ρ, ΡΠ°ΠΊΠΈΠ΅ ΠΊΠ°ΠΊ dCTCF ΠΈ CP 190. ΠΠ΄Π½Π°ΠΊΠΎ ΠΈΡ ΡΠΎΠ»Ρ Π² ΡΠ΅Π³ΡΠ»ΡΡΠΈΠΈ ΡΠ°Π±ΠΎΡΡ Π³Π΅Π½Π° Abd-B ΠΎΡΡΠ°Π΅ΡΡΡ Π½Π΅ ΡΠΎΠ²ΡΠ΅ΠΌ ΡΡΠ½ΠΎΠΉ.
Π¦Π΅Π»ΡΡ Π½Π°ΡΡΠΎΡΡΠ΅ΠΉ ΡΠ°Π±ΠΎΡΡ ΡΡΠ°Π»ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΡ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠΉ ΠΌΠ΅ΠΆΠ΄Ρ Π³ΡΠ°Π½ΠΈΡΠ°ΠΌΠΈ Fab-7 ΠΈ Fab-8 ΠΈ ΠΏΡΠΎΠ²Π΅ΡΠΊΠ° ΠΈΡ ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΠΈ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΎΠ²Π°ΡΡ Ρ ΠΏΡΠΎΠΌΠΎΡΠΎΡΠ½ΠΎΠΉ ΠΎΠ±Π»Π°ΡΡΡΡ ΡΠ΅ΠΌΠ°. Abd-B.
ΠΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠΉ ΠΎΡΠ½ΠΎΠ²ΠΎΠΉ Π΄Π°Π½Π½ΠΎΠΉ ΡΠ°Π±ΠΎΡΡ ΠΏΠΎΡΠ»ΡΠΆΠΈΠ»Π° ΠΌΠΎΠ΄Π΅Π»ΡΠ½Π°Ρ ΡΠΈΡΡΠ΅ΠΌΠ°, ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½Π½Π°Ρ Π² Π½Π°ΡΠ΅ΠΉ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠΈΠΈ ΠΈ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡΡΠ°Ρ ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΡΠΈΡΠΎΠ²Π°ΡΡ ΡΠ»Π΅ΠΌΠ΅Π½ΡΡ, ΡΠΏΠΎΡΠΎΠ±Π½ΡΠ΅ ΠΊ ΠΊΠΎΠΌΠΌΡΠ½ΠΈΠΊΠ°ΡΠΈΠΈ Π½Π° Π±ΠΎΠ»ΡΡΠΈΡ Π΄ΠΈΡΡΠ°Π½ΡΠΈΡΡ . ΠΡΠΈ ΠΏΠΎΠΌΠΎΡΠΈ Π½Π΅Π΅ ΠΌΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π»ΠΈ ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΡ Π³ΡΠ°Π½ΠΈΡΡ Fab-8 ΠΈ Π΅Π΅ ΡΠΎΡΡΠ°Π²Π½ΡΡ ΡΠ°ΡΡΠ΅ΠΉ ΠΊ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ Π½Π° Π±ΠΎΠ»ΡΡΠΎΠΌ ΡΠ°ΡΡΡΠΎΡΠ½ΠΈΠΈ ΡΠΎ ΡΠ²ΠΎΠ΅ΠΉ ΠΊΠΎΠΏΠΈΠ΅ΠΉ, Ρ Π³ΡΠ°Π½ΠΈΡΠ΅ΠΉ Fab-7 ΠΈ Ρ ΠΏΡΠ΅Π΄ΠΏΡΠΎΠΌΠΎΡΠΎΡΠ½ΠΎΠΉ ΠΎΠ±Π»Π°ΡΡΡΡ Π³Π΅Π½Π° Abd-B. ΠΡΠΎΠΌΠ΅ ΡΠΎΠ³ΠΎ, Π² Π΄Π°Π½Π½ΠΎΠΉ ΡΠ°Π±ΠΎΡΠ΅ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΡΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠΎΠ»ΠΈ Π±Π΅Π»ΠΊΠ° dCTCF Π² ΠΎΡΡΡΠ΅ΡΡΠ²Π»Π΅Π½ΠΈΠΈ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠΉ Π½Π° Π±ΠΎΠ»ΡΡΠΈΡ Π΄ΠΈΡΡΠ°Π½ΡΠΈΡΡ .
Π²ΡΠ²ΠΎΠ΄Ρ.
1. ΠΡΠΎΠ΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΠΎΠ²Π°Π½Π° ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΡ ΠΠ°Π¬-8 ΠΈΠ½ΡΡΠ»ΡΡΠΎΡΠ° ΠΊ ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠ°Π½ΠΈΡ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ ΡΠΎ ΡΠ²ΠΎΠ΅ΠΉ ΠΊΠΎΠΏΠΈΠ΅ΠΉ Π½Π° Π±ΠΎΠ»ΡΡΠΎΠΉ Π΄ΠΈΡΡΠ°Π½ΡΠΈΠΈ.
2. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ΅ ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΠ΅ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΌΠ΅ΠΆΠ΄Ρ ΠΠ°Π¬-8 ΠΈΠ½ΡΡΠ»ΡΡΠΎΡΠ°ΠΌΠΈ Π·Π°Π²ΠΈΡΠΈΡ ΠΎΡ ΠΈΡ Π²Π·Π°ΠΈΠΌΠ½ΠΎΠΉ ΠΎΡΠΈΠ΅Π½ΡΠ°ΡΠΈΠΈ.
3. ΠΠ΅Π»ΠΎΠΊ <!Π‘Π’Π‘Π, ΡΠ²ΡΠ·ΡΠ²Π°ΡΡΠΈΠΉΡΡ Ρ ΠΈΠ½ΡΡΠ»ΡΡΠΎΡΠΎΠΌ ΠΠ°Π¬-8, ΡΠΏΠΎΡΠΎΠ±Π΅Π½ ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠΈΠ²Π°ΡΡ Π΄ΠΈΡΡΠ°Π½ΡΠΈΠΎΠ½Π½ΡΠ΅ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ.
4. ΠΠΏΠ΅ΡΠ²ΡΠ΅ ΠΏΡΠΎΠ΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΠΎΠ²Π°Π½ΠΎ, ΡΡΠΎ Π³Π΅ΡΠ΅ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ½ΡΠ΅ Π³ΡΠ°Π½ΠΈΡΡ, ΠΠ°Π¬-8 ΠΈ ΠΠ°Π¬-7, ΡΠΏΠΎΡΠΎΠ±Π½Ρ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΎΠ²Π°ΡΡ.
5. ΠΠΎΠΊΠ°Π·Π°Π½Π° ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΡ Π³ΡΠ°Π½ΠΈΡ ΠΠ°Π¬-8 ΠΈ ΠΠ°Π¬-7 Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΎΠ²Π°ΡΡ Ρ ΠΏΡΠΎΠΌΠΎΡΠΎΡΠ½ΠΎΠΉ ΠΎΠ±Π»Π°ΡΡΡΡ ΠΠ¬ΠΉ-Π.
Π‘ΠΏΠΈΡΠΎΠΊ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ
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